On 27 May 2025, ECHA released IUCLID 6 (v9.0.1). Companies can now use it to prepare intention notifications under the EU Drinking Water Directive and submit notifications for microplastic restrictions under REACH.

The "micro - plastic restriction" regulation came into effect on October 17, 2023.

On 20 May 2025, the European Chemicals Agency (ECHA) announced the official launch of its newly upgraded Classification and Labelling (C&L) Inventory in the ECHA CHEM database. This update aims to enhance the accessibility and transparency of classification information for users and to lay the foundation for future data expansion.

In May 2025, the European Chemicals Agency (ECHA) released the fourth edition of the Catalogue of borderline cases between articles and substances/mixtures.

On April 29, 2025 , the European Chemicals Agency (ECHA) unveiled a proposal to restrict the use of carcinogenic hexavalent chromium (Cr(VI)) substances across the EU. The measure aims to safeguard human health and the environment from the cancer risks associated with these chemicals.

The reporting system is expected to be operational by December 2025.

ECHA added six new substance testing proposals and opened a public consultation period, inviting stakeholders to submit comments by June 2.

On April 3, 2025, during a meeting of the Competent Authorities for REACH and CLP (CARACAL), the European Commission proposed the latest amendments to the REACH Regulation, sparking strong objections from the European Chemical Industry Council (Cefic), the European Federation of Construction Chemicals (EFCC), and the International Fragrance Association (IFRA). The three industry associations directly criticized the revision draft for contradicting the EU's policy objectives of enhancing industrial competitiveness, warning that it could severely impact small and medium-sized enterprises (SMEs).

In April 2025, ECHA released its 2024 annual work report, showcasing its significant achievements and challenges in chemical regulation over the past year.

ECHA announced the addition of 14 new substance testing proposals and invited public comments by May 2.