On May 6, 2025, the Ministry of Ecology and Environment of China (MEE) added 44 substances to the Inventory of Existing Chemical Substances in China (IECSC), and revised the permitted uses of two substances.
CIRS warmly reminds related enterprises that they must know whether their substances are new or existing substances. The Provisions on Environmental Administration of New Chemical Substances (MEE Order 12) requires enterprises to complete new substance registration/record before manufacturing or importing, or they may face various punishments.
To find out whether a substance is listed in IECSC, please search our free tool – ChemRadar.
The MEE issued Announcement No. 9 of 2025, declaring updates to the IECSC.
Industry Alert: Due Diligence Required Before Registration
Before registering new chemical substances, companies should verify whether the substance is new. If the substance is not listed in the IECSC, it is necessary to engage a professional agency to perform a confidential search to determine if it qualifies as a new chemical substance, thus avoiding wasting resources.
Two Typical Cases:
Case 1: A company failed to conduct a search and erroneously declared a substance, already listed in the confidential section of the inventory, as a new substance, leading to wasted costs in testing, time, and human resources.
Case 2: Another company was able to halt its declaration process in time due to dynamic updates to the inventory, thereby reducing losses.
Conducting a search not only avoids futile declarations but also provides a basis for companies to address subsequent disputes. As the frequency of updates to the inventory increases, companies must stay alert and combine professional services to optimize compliance strategies.
This update is a crucial step by the MEE to strengthen the full lifecycle management of chemical substances, aiming to balance industry innovation with ecological safety. In the future, the dynamic adjustment mechanism of the inventory will be further refined to support the environmental risk prevention and control goals for chemical substances during the 14th Five-Year Plan period.
Details
Annex 1
Additions to the Inventory of Existing Chemical Substances in China
SN | Name | Alias | Molecular Formula | CAS No. or Serial Code |
1 | Butanoic acid, 2-hydroxy-4-(methylthio)- |
| C5H10O3S | 583-91-5 |
2 | Diisopropyl xanthogen disulfide | Accelerator DIP | C8H14O2S4 | 105-65-7 |
3 | Benzoic acid, 4-nitro-, ammonium salt (1:1) | Ammonium p-nitrobenzoate | C7H5NO4.H3N | 19416-70-7 |
4 | Dodecanedioic acid, ammonium salt (1:?) |
| C12H22O4.xH3N | 59864-79-8 |
5 | Triammonium citrate |
| C6H17N3O7 | 3458-72-8 |
6 | 1-(Chloromethyl)-4-fluorobenzene | p-Fluorobenzyl chloride; 4-Fluorobenzyl chloride; Benzene,1-(chloromethyl)-4-fluoro- | C7H6ClF | 352-11-4 |
7 | 4-Thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)- | Tazobactam | C10H12N4O5S | 89786-04-9 |
Annex 2
Registered chemical substances added to the Inventory of Existing Chemical Substances in China
SN | Class Name | Serial Code | Scope of New Usage Management |
1 | Halogeno-dihydro-oxoindenecarboxylic acid alkyl ester | 9911 | Industrial uses other than those permitted for use. Permitted uses: Pesticide intermediate |
2 | Aluminoxanes, alkyl, alkyl group-terminated, reaction products with silica, halogenated, reaction products with bis(alkyl-alkylcyclopentadienyl]dihalogeno (transition metal) | 9912 |
|
3 | [Amino-(alkylamino)benzoyl]-(azaaryl) alanine alkyl ester | 9913 |
|
4 | 1H-Pyrazole-carbonyl fluoride, substituted | 9914 | Industrial uses other than those permitted for use. Permitted uses: Pesticide intermediate |
5 | Halogenosulfonic acid alkali metal salt | 9915 |
|
6 | Formaldehyde, telomer with aromaticamine, benzenediol and aromaticalkene | 9916 | Industrial uses other than those permitted for use.
Permitted uses: Curing agent for adhesive mortar used in construction work |
7 | Amides, tallow, N,N-bis(substituted alkyl) | 9917 | Industrial uses other than those permitted for use Permitted uses: Lubricant additives |
8 | Alkyloxy(aliphatic polyol) | 9918 |
|
SN | Class Name | Serial Code | Scope of New Usage Management |
9 | Reaction products of disubstituted arene and alkanol | 9919 |
|
10 | Bis(halogenoaryl)-dioxo-dihydropyrrolopyrrole, sulfo derivs. | 9920 | Industrial uses other than those permitted for use Permitted uses: LCD colour filter photoresist material |
11 | Alkyloxyphenyl-nitrophenyl-oxoheteropolycyclic-carboxylic acid, ethyl ester | 9921 |
|
12 | Metal silicate | 9922 |
|
13 | Polyalkylalkoxycyclohexane | 9923 | Industrial uses other than those permitted for use. Permitted uses: Fragrance ingredients in oral care products |
14 | Hydroxy-oxoheteroaromatic metallic compounds | 9924 | Industrial uses other than those permitted for use. Permitted uses: Paint catalyst |
15 | 2H-Indazole-7-carboxamide, heteromonocyclic phenyl-, alkylcarbomonocyclic sulfonate, hydrate | 9925 | Industrial uses other than those permitted for use. Permitted uses: Pharmaceutical intermediates |
16 | Reactive red azo dyes | 9926 |
|
17 | Sulfo(aliphatic polycarboxylic acid)[(polyhalogenoalkoxy)-(alkyl)alkyl] esters, sodium salt | 9927 |
|
18 | Alkenoic acid, aryl ester | 9928 |
|
19 | Reactionproductsof diazotised benzenesulfonic acid, substituted[[(sulfooxy)alkyl]sulfonyl]-, subsequently coupled with benzoic acid, multiamino-, further coupled with diazotised alkanol,[(aminoaryl)sulfonyl]-, (hydrogen sulfate), metal salts | 9929 |
|
20 | Bis(cycloalkylalkyl) ether | 9930 | Industrial uses other than those permitted for use. Permitted uses: flavoring materials |
SN | Class Name | Serial Code | Scope of New Usage Management |
21 | Lithium ((tert-butoxycarbonyl)piperidin-3-yl)aryl-2H-heteropolycyclic-7-carboxylate | 9931 |
|
22 | N-[4-[[2-Amino-multihydro-4-substituted-6- pteridinyl)alkyl]amino] alkyl]-L-glutamic acid | 9932 |
|
23 | Polyhalogenated phosphorous acid, alkyl ester | 9933 |
|
24 | Oxa(polycyclic arene), bis(hydroxyaryl)-oxo-, reaction products with aniline and epichlorohydrin | 9934 |
|
25 | 4-[[(Halodialkylphenyl)alkanoyl]alkylamino]-alkoxy-N-phenylpiperidinecarbox amide | 9935 | Industrial uses other than those permitted for use. Permitted uses: Pesticide intermediate |
26 | Ethyl alkyl-substitutedcycloalkanecarboxylate | 9936 |
|
27 | Methyl(alkylcyclohexyl)biphenyl | 9937 |
|
28 | 3-[(2R)-2-amino-2-arylalkyl]-5-(2-halo-3-alkoxyphenyl)-1-{[2-halo-6-substituted phenyl]alkyl}-6-alkypyrimidine-2,4(1H,3H)-dione 2-hydroxyarylcarboxylate (1:1) | 9938 | Industrial uses other than those permitted for use. Permitted uses: Pharmaceutical intermediates |
29 | N-Substituted-L-prolinamide | 9939 |
|
30 | (Amino-thiadiazolyl)-[alkyl-[(alkyl)oxy]-oxopropanyl]oxyiminoacetic acid | 9940 |
|
31 | Alkyl (((alkyl-polyarylmethylamino-1H-pyrazolyl) ureido)alkyl)carbamate | 9941 |
|
SN | Name | Molecular Formula | CAS No. or Serial Code | Scope of New Usage Management |
32 | Methyl (2E)-2-(2-chloromethylphenyl)-3-methoxy-2-acrylate | C12H13ClO3 | 117428-51-0 | Industrial uses other than those permitted for use. Permitted uses: Pesticide intermediate |
33 | Thiirane, 2,2'-[thiobis(methylene)]bis- | C6H10S3 | 188829-97-2 |
|
34. | 1,3,2-Dioxathiolane, 2,2-dioxide | C2H4O4S | 1072-53-3 |
|
35 | 1H-Imidazole-1-propanenitrile, 2-ethyl-ar-methyl- | C9H13N3 | 568591-00-4 |
|
36 | Alkenes, C10-16 α-, reaction products with (6E)-7, 11-dimethyl-3-methylene-1,6,10-dodecatriene,hydrogenated | (CnH2n • C15H24) • H2 n=10~16 | 1481694-12-5 |
|
37 | Fatty acids,C12-14,reaction products with sulfur trioxide, sodium salts | Undecided | 2215087-54-8 |
|
Annex 3
Existing Substances with Changes to the Permitted Uses
SN | Class Name | Serial Code | Scope of New Usage Management |
1 | Imidazolium, dialkyl-, branched alkylbenzenesulfonates | 9645 | Industrial uses other than those permitted for use. Permitted uses: Antistatic agent for resins |
2 | Dialkyl phosphate metal salt | 9608 | Industrial uses other than those permitted for use. Permitted uses: Automotive engine oil lubricant additives, gas engine oil lubricant additives |
Note: According to Annexes 1 and 2, a total of 44 chemical substances have been incorporated into the IECSC. The MEE emphasizes that by the end of 2025, all chemicals that have completed their regular notifications under the former MEP Order No. 7 will be included in the IECSC.
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Further Information
The Inventory of Existing Chemical Substances in China – IECSC (2013 and updates)