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44 Substances Added into China’s Inventory of Existing Chemical Substances

from CIRS by

On May 6, 2025, the Ministry of Ecology and Environment of China (MEE) added 44 substances to the Inventory of Existing Chemical Substances in China (IECSC), and revised the permitted uses of two substances. 

CIRS warmly reminds related enterprises that they must know whether their substances are new or existing substances. The Provisions on Environmental Administration of New Chemical Substances (MEE Order 12) requires enterprises to complete new substance registration/record before manufacturing or importing, or they may face various punishments.

To find out whether a substance is listed in IECSC, please search our free tool – ChemRadar.

The MEE  issued Announcement No. 9 of 2025, declaring updates to the IECSC.

Industry Alert: Due Diligence Required Before Registration

Before registering new chemical substances, companies should verify whether the substance is new. If the substance is not listed in the IECSC, it is necessary to engage a professional agency to perform a confidential search to determine if it qualifies as a new chemical substance, thus avoiding wasting resources.

Two Typical Cases:

Case 1: A company failed to conduct a search and erroneously declared a substance, already listed in the confidential section of the inventory, as a new substance, leading to wasted costs in testing, time, and human resources.

Case 2: Another company was able to halt its declaration process in time due to dynamic updates to the inventory, thereby reducing losses.

Conducting a search not only avoids futile declarations but also provides a basis for companies to address subsequent disputes. As the frequency of updates to the inventory increases, companies must stay alert and combine professional services to optimize compliance strategies.

This update is a crucial step by the MEE to strengthen the full lifecycle management of chemical substances, aiming to balance industry innovation with ecological safety. In the future, the dynamic adjustment mechanism of the inventory will be further refined to support the environmental risk prevention and control goals for chemical substances during the 14th Five-Year Plan period.

Details

Annex 1

Additions to the Inventory of Existing Chemical Substances in China 

SN

Name

Alias

Molecular Formula

CAS No. or Serial Code 

1

Butanoic acid, 2-hydroxy-4-(methylthio)-

 

C5H10O3S

583-91-5

2

Diisopropyl xanthogen disulfide

Accelerator DIP

C8H14O2S4

105-65-7

3

Benzoic acid, 4-nitro-, ammonium salt (1:1)

Ammonium p-nitrobenzoate

C7H5NO4.H3N

19416-70-7

4

Dodecanedioic acid, ammonium salt (1:?)

 

C12H22O4.xH3N

59864-79-8

5

Triammonium citrate

 

C6H17N3O7

3458-72-8

6

1-(Chloromethyl)-4-fluorobenzene

p-Fluorobenzyl chloride; 4-Fluorobenzyl chloride;

Benzene,1-(chloromethyl)-4-fluoro-

C7H6ClF

352-11-4

7

4-Thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid, 3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)-

Tazobactam

C10H12N4O5S

89786-04-9

Annex 2

Registered chemical substances added to the Inventory of Existing Chemical Substances in China

SN

Class Name

Serial Code

Scope of New Usage Management

1

Halogeno-dihydro-oxoindenecarboxylic acid alkyl ester

9911

Industrial uses other than those permitted for use.

Permitted uses: Pesticide intermediate

2

Aluminoxanes, alkyl, alkyl group-terminated, reaction products with silica, halogenated, reaction products with bis(alkyl-alkylcyclopentadienyl]dihalogeno (transition metal)

9912

 

3

[Amino-(alkylamino)benzoyl]-(azaaryl) alanine alkyl ester

9913

 

4

1H-Pyrazole-carbonyl fluoride, substituted

9914

Industrial uses other than those permitted for use.

Permitted uses: Pesticide intermediate

5

Halogenosulfonic acid alkali metal salt

9915

 

6

Formaldehyde, telomer with aromaticamine, benzenediol and aromaticalkene

9916

Industrial uses other than those permitted for use.

 

Permitted uses: Curing agent for adhesive mortar used in construction work

7

Amides, tallow, N,N-bis(substituted alkyl)

9917

Industrial uses other than those permitted for use

Permitted uses: Lubricant additives

8

Alkyloxy(aliphatic polyol)

9918

 

SN

Class Name

Serial Code

Scope of New Usage Management

9

Reaction products of disubstituted arene and alkanol

9919

 

10

Bis(halogenoaryl)-dioxo-dihydropyrrolopyrrole, sulfo derivs.

9920

Industrial uses other than those permitted for use

Permitted uses: LCD colour filter photoresist material

11

Alkyloxyphenyl-nitrophenyl-oxoheteropolycyclic-carboxylic acid, ethyl ester

9921

 

12

Metal silicate

9922

 

13

Polyalkylalkoxycyclohexane

9923

Industrial uses other than those permitted for use.

Permitted uses: Fragrance ingredients in oral care products

14

Hydroxy-oxoheteroaromatic metallic compounds

9924

Industrial uses other than those permitted for use.

Permitted uses: Paint catalyst

15

2H-Indazole-7-carboxamide, heteromonocyclic phenyl-, alkylcarbomonocyclic sulfonate, hydrate

9925

Industrial uses other than those permitted for use.

Permitted uses: Pharmaceutical intermediates

16

Reactive red azo dyes

9926

 

17

Sulfo(aliphatic polycarboxylic acid)[(polyhalogenoalkoxy)-(alkyl)alkyl] esters, sodium salt

9927

 

18

Alkenoic acid, aryl ester

9928

 

19

Reactionproductsof diazotised benzenesulfonic acid, substituted[[(sulfooxy)alkyl]sulfonyl]-, subsequently coupled with benzoic acid, multiamino-, further coupled with diazotised alkanol,[(aminoaryl)sulfonyl]-, (hydrogen sulfate), metal salts

9929

 

20

Bis(cycloalkylalkyl) ether

9930

Industrial uses other than those permitted for use.

Permitted uses: flavoring materials

SN

Class Name

Serial Code

Scope of New Usage Management

21

Lithium ((tert-butoxycarbonyl)piperidin-3-yl)aryl-2H-heteropolycyclic-7-carboxylate

9931

 

22

N-[4-[[2-Amino-multihydro-4-substituted-6- pteridinyl)alkyl]amino] alkyl]-L-glutamic acid

9932

 

23

Polyhalogenated phosphorous acid, alkyl ester

9933

 

24

Oxa(polycyclic arene), bis(hydroxyaryl)-oxo-, reaction products with aniline and epichlorohydrin

9934

 

25

4-[[(Halodialkylphenyl)alkanoyl]alkylamino]-alkoxy-N-phenylpiperidinecarbox amide

9935

Industrial uses other than those permitted for use.

Permitted uses: Pesticide intermediate

26

Ethyl alkyl-substitutedcycloalkanecarboxylate

9936

 

27

Methyl(alkylcyclohexyl)biphenyl

9937

 

28

3-[(2R)-2-amino-2-arylalkyl]-5-(2-halo-3-alkoxyphenyl)-1-{[2-halo-6-substituted phenyl]alkyl}-6-alkypyrimidine-2,4(1H,3H)-dione 2-hydroxyarylcarboxylate (1:1)

9938

Industrial uses other than those permitted for use.

Permitted uses: Pharmaceutical intermediates

29

N-Substituted-L-prolinamide

9939

 

30

(Amino-thiadiazolyl)-[alkyl-[(alkyl)oxy]-oxopropanyl]oxyiminoacetic acid

9940

 

31

Alkyl (((alkyl-polyarylmethylamino-1H-pyrazolyl) ureido)alkyl)carbamate

 9941

 

SN

Name

Molecular Formula

CAS No. or Serial Code

Scope of New Usage Management

32

Methyl (2E)-2-(2-chloromethylphenyl)-3-methoxy-2-acrylate

C12H13ClO3

117428-51-0

Industrial uses other than those permitted for use.

Permitted uses: Pesticide intermediate

33

Thiirane, 2,2'-[thiobis(methylene)]bis-

C6H10S3

188829-97-2

 

34.

1,3,2-Dioxathiolane, 2,2-dioxide

C2H4O4S

1072-53-3

 

35

1H-Imidazole-1-propanenitrile, 2-ethyl-ar-methyl-

C9H13N3

568591-00-4

 

36

Alkenes, C10-16 α-, reaction products with (6E)-7, 11-dimethyl-3-methylene-1,6,10-dodecatriene,hydrogenated

(CnH2n • C15H24) • H2 n=10~16

1481694-12-5

 

37

Fatty acids,C12-14,reaction products with sulfur trioxide, sodium salts

Undecided

2215087-54-8

 

Annex 3

Existing Substances with Changes to the Permitted Uses

SN

Class Name

Serial Code

Scope of New Usage Management

1

Imidazolium, dialkyl-, branched alkylbenzenesulfonates

9645

Industrial uses other than those permitted for use.

Permitted uses: Antistatic agent for resins

2

Dialkyl phosphate metal salt

9608

Industrial uses other than those permitted for use.

Permitted uses: Automotive engine oil lubricant additives, gas engine oil lubricant additives

Note: According to Annexes 1 and 2, a total of 44 chemical substances have been incorporated into the IECSC. The MEE emphasizes that by the end of 2025, all chemicals that have completed their regular notifications under the former MEP Order No. 7 will be included in the IECSC.

If you need any assistance or have any questions, please get in touch with us via service@cirs-group.com.

Further Information

MEE Notice in Chinese

The Inventory of Existing Chemical Substances in China – IECSC (2013 and updates)

  

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